An Introduction to Metabolism
Campbell Chapter 6

1. Define the terms metabolic, catabolic, and anabolic.

2. State the first and second laws of thermodynamics.

3. What is free energy?

4. What conditions are spontaneous processes trying to satisfy?

5. Consider the reaction G = H-TS. Under what conditions would a reaction proceed spontaneously?

6. Explain exergonic and endergonic reactions in terms of free energy.

7. Why are cells concerned with avoiding metabolic equilibrium?

8. What is energy coupling? Provide an example.

9. Describe the structure of ATP.

10. How is ATP used by cells?

11. What about the structure of ATP makes it useful as an energy currency?

12. What change in free energy accompanies the reaction ATP ADP + P?

13. Draw a graph which shows both the change in free energy as a non-catalyzed reaction proceeds as well as that for an enzyme-catalyzed reaction.

14. How do enzymes lower the activation energy of a reaction?

15. Use a simple graph to explain the affect of both temperature and pH on enzyme activity.

16. Describe the role played by activators and inhibitors in controlling enzymatic reactions.

17. What is the difference between competitive and noncompetitive inhibition?

18. Describe allosteric regulation, cooperativity, and feedback inhibition.

19. Describe the relationship between the concentration of a substrate and the rate of an enzyme-catalyzed reaction.