The Chromosomal Basis of Inheritance

Campbell Chapter 14

1. What is meant by the term linked genes?

2. Looking at progeny, how might one guess that two genes are linked?

3. When studying linked genes, how do you explain the appearance of progeny that do not share either parental phenotype?

4. How can recombination data be used to map genetic loci?

5. How does a linkage map differ from an actual picture of a chromosome?

6. Describe the X-Y, X-O, Z-W, and haploid-diploid systems of sex determination.

7. What is meant by the term sex-linked gene?

8. In the X-Y system, why are sex-linked disorders more prevalent in males than females?

9. What is meant by X-inactivation and when does it occur?

10. What is a Barr body?

11. How does nondisjunction occur?

12. Define the common types of aneuploidy.

13. Define deletion, duplication, inversion, and translocation alterations of chromosomes.

14. Explain genomic imprinting (even though it seems like utter craziness).

15. What are triplet repeats and what is their connection to fragile X syndrome?

16. The are extranuclear genes?