The Chromosomal Basis of Inheritance

Chapter 15

1. Alleles are supposed to assort independently into gametes. How do linked genes violate this law?

2. Looking at progeny, how might one guess that two genes are linked?

3. When studying linked genes, how do you explain the appearance of progeny that do not share either parental phenotype?

4. How can recombination data be used to map genetic loci?

5. How does a linkage map differ from the actual organization of a chromosome?

6. Describe the X-Y, X-O, Z-W, and haplo-diploid systems of sex determination.

7. What is meant by the term sex-linked gene?

8. In the X-Y system, why are sex-linked disorders more prevalent in males than females?

9. What is meant by X-inactivation and when does it occur?

10. How does nondisjunction occur?

11. Define the common types of aneuploidy.

12. Define deletion, duplication, inversion, and translocation alterations of chromosomes.

13. Explain genomic imprinting (even though it seems like utter craziness).

14. What are extranuclear genes and how are they inherited?